Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis
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چکیده
منابع مشابه
Glutathione Decrement Drives Thermogenic Program In Adipose Cells
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione (GSH). Moreover, the treatment with a GSH depleting agent, buthionine sulfoximine (BSO), recapitulates the effect of co...
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The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles. Here we report the creation of mice with targeted ablation of all three Jnk genes in neurons. Compound JNK-deficient neurons are dependent on autophagy for survival. This autophagic response is caused by FoxO-induce...
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20. M. R. Bennett, J. Hasty, Nat. Rev. Genet. 10, 628–638 (2009). 21. T. Y. Tsai et al., Science 321, 126–129 (2008). 22. J. K. Kim, D. B. Forger, Mol. Syst. Biol. 8, 630 (2012). 23. B. Novák, J. J. Tyson, Nat. Rev. Mol. Cell Biol. 9, 981–991 (2008). 24. E. L. O’Brien, E. Van Itallie, M. R. Bennett, Math. Biosci. 236, 1–15 (2012). 25. F. Naqib et al., Phys. Rev. E Stat. Nonlin. Soft Matter Phys...
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ژورنال
عنوان ژورنال: iScience
سال: 2019
ISSN: 2589-0042
DOI: 10.1016/j.isci.2019.11.006